Initiating factors that cause the disease are poorly understood and are thought to involve a genetic predisposition ( Kenealy et al., 2003) as well as environmental influences ( Marrie, 2004). This debilitating disease involves an attack by the immune system against antigens of the central nervous system (CNS), especially antigens derived from oligodendrocytes that constitute the myelin sheaths surrounding axons. Multiple sclerosis (MS) is an autoimmune disease affecting at least 1 in 1000 people in the US and is anticipated to become substantially more prevalent in coming years ( Hirtz et al., 2007). This therapy is shown here to reverse inflammation induced paralysis, to reduce disease associated reduction in sensitivity to touch, to prevent the onset of allodynia, to reverse disease associated loss of body weight, and to suppress CNS glial activation associated with disease progression in this model. Furthermore, we tested the ability of our recently characterized anti-inflammatory IL-10 gene therapy to treat the autoimmune inflammation induced behavioral symptoms and tissue histopathological changes. We demonstrate periods of both decreased responsiveness to touch that precedes the onset of hind limb paralysis, and increased responsiveness (allodynia) that occurs during the period of motor deficit amelioration traditionally referred to as symptom remission. The current work contains the first assessment of hind paw mechanical allodynia (von Frey test) over the course of a relapsing-remitting myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis (MOG-EAE) rat model of MS and establishes the utility of this model in examining autoimmune induced sensory dysfunction. To date, there have been very few investigations into sensory disturbances in animal models of MS. In recent years, neuropathic pain has been recognized as a prevalent symptom of MS in a majority of patients. A variety of animal models of MS have been developed that share many of the pathological hallmarks of MS including motor deficits (ascending paralysis), demyelination and axonal damage of central nervous system (CNS) tissue. If you purchase a LOMOS® product you will also be supporting the project "One Percent For The Children".Multiple Sclerosis (MS) is an autoimmune inflammatory disease that presents clinically with a range of symptoms including motor, sensory, and cognitive dysfunction as well as demyelination and lesion formation in brain and spinal cord. Perfect for exercise, gymnastics, physical therapy and rehab training.Burst proof thanks to anti-burst function.High quality fitness ball and an air pump.The ball can then be sealed tightly with the stopper. Items Delivered: The air pump included in the delivery allows for the ball to be inflated quickly and easily. Both feet should be able to touch the ground. When sitting on the ball, your thighs should be horizontal to the floor, with your lower legs at a 90° angle. The corresponding body size is put in brackets: 65 cm (155cm - 175cm) and 75 cm (175cm - 185cm). The LOMOS® exercise ball is available in two sizes that are most commonly requested. Your Perfect Size:Your height will dictate the best choice for the exercise ball size. The ball can be easily cleaned with a damp cloth. The abrasion resistant and non-slip material ensures a safe grip during exercises and is particularly durable. Material & Care: The high quality PVC with anti-burst function is tear resistant and highly durable (load capacity of up to 250kg). As it works as a great tool for yoga, Pilates, abdominal and back exercises, aerobics, CrossFit, pregnancy gymnastics, physical therapy, and much more, the LOMOS® exercise ball is a must-have for anyone who wants to do improve their health and appearance! In addition to working out, the LOMOS® exercise ball can also be used as a seat at home or in your office and can ease back and neck pain.
The ball with a 75 cm in diameter is for people of 175-185cm.Īreas of Application:The LOMOS® exercise ball is a versatile fitness accessory that trains the whole body and improves your posture. The diameter of 65cm is suitable for people 155-175cm tall.
#Wechsel pain and rehab professional
The professional LOMOS® fitness ball does a great job, offers numerous exercise options and thus activates different muscle groups.Fitness ball for varied uses: Whether you practice yoga, Pilates, aerobics, CrossFit, pregnancy gymnastics, physical therapy and rehabilitation, or want to achieve better posture in the office.
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